TY - JOUR T1 - Immunotherapy Approaches Targeting Regulatory T-Cells JF - Anticancer Research JO - Anticancer Res SP - 997 LP - 1003 VL - 32 IS - 3 AU - HIDEYA ONISHI AU - TAKASHI MORISAKI AU - MITSUO KATANO Y1 - 2012/03/01 UR - http://ar.iiarjournals.org/content/32/3/997.abstract N2 - The immune system prevents establishment and progression of cancer through innate and adaptive surveillance. However, some cancerous cells successfully evade the immune system. Regulatory T-cells (Tregs) facilitate such evasion. Tregs may be the factor responsible for the limited success of human tumor immunotherapy to date. To improve immunotherapy, it is thought that the number of Tregs and their functions should be inhibited in patients with advanced cancer. In this review, we focus on recent immunotherapy efforts targeting Tregs. ER -