RT Journal Article
SR Electronic
T1 Metastatic Renal Cell Carcinoma Treated Sequentially with Multiple VEGF Receptor-targeted Inhibitors – A Case Report
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 697
OP 700
VO 32
IS 2
A1 CLAUDE LINASSIER
A1 DELPHINE CARMIER
A1 PIERRE COMBE
A1 BENJAMIN FAIVRE D'ARCIER
A1 FRANCK BRUYERE
A1 BERANGERE NARCISO
YR 2012
UL http://ar.iiarjournals.org/content/32/2/697.abstract
AB Six targeted agents [sorafenib, sunitinib, temsirolimus, bevacizumab (plus interferon), everolimus and pazopanib] have been approved for the treatment of patients with metastatic renal cell carcinoma. As disease progression is inevitable, most patients will receive several lines of treatment. However, the choice regarding which sequence of drugs to use remains unclear, particularly concerning the drug class, i.e. those targeting the vascular endothelial growth factor (receptor) [VEGF(R)] pathway versus those acting on the mammalian target of rapamycin pathway. There appears to be no absolute crossresistance between tyrosine kinase inhibitors (TKIs) acting on the VEGF(R) pathway, and there have been numerous reports of two TKIs being successfully used in sequence. We report the case of a 63-year-old woman who responded for 24 months to three successive lines of treatment with different TKIs (sunitinib, axitinib and sorafenib). This suggests that TKIs targeting VEGFR should be considered as individual drugs and not as a single class.