TY - JOUR T1 - Metastatic Renal Cell Carcinoma Treated Sequentially with Multiple VEGF Receptor-targeted Inhibitors – A Case Report JF - Anticancer Research JO - Anticancer Res SP - 697 LP - 700 VL - 32 IS - 2 AU - CLAUDE LINASSIER AU - DELPHINE CARMIER AU - PIERRE COMBE AU - BENJAMIN FAIVRE D'ARCIER AU - FRANCK BRUYERE AU - BERANGERE NARCISO Y1 - 2012/02/01 UR - http://ar.iiarjournals.org/content/32/2/697.abstract N2 - Six targeted agents [sorafenib, sunitinib, temsirolimus, bevacizumab (plus interferon), everolimus and pazopanib] have been approved for the treatment of patients with metastatic renal cell carcinoma. As disease progression is inevitable, most patients will receive several lines of treatment. However, the choice regarding which sequence of drugs to use remains unclear, particularly concerning the drug class, i.e. those targeting the vascular endothelial growth factor (receptor) [VEGF(R)] pathway versus those acting on the mammalian target of rapamycin pathway. There appears to be no absolute crossresistance between tyrosine kinase inhibitors (TKIs) acting on the VEGF(R) pathway, and there have been numerous reports of two TKIs being successfully used in sequence. We report the case of a 63-year-old woman who responded for 24 months to three successive lines of treatment with different TKIs (sunitinib, axitinib and sorafenib). This suggests that TKIs targeting VEGFR should be considered as individual drugs and not as a single class. ER -