TY - JOUR T1 - Reported Intake of Selected Micronutrients and Risk of Colorectal Cancer: Results from a Large Population-based Case–control Study in Newfoundland, Labrador and Ontario, Canada JF - Anticancer Research JO - Anticancer Res SP - 687 LP - 696 VL - 32 IS - 2 AU - ZHUOYU SUN AU - YUN ZHU AU - PEIZHONG PETER WANG AU - BARBARA ROEBOTHAN AU - JING ZHAO AU - JINHUI ZHAO AU - ELIZABETH DICKS AU - MICHELLE COTTERCHIO AU - SHARON BUEHLER AU - PETER T. CAMPBELL AU - JOHN R. MCLAUGHLIN AU - PATRICK S. PARFREY Y1 - 2012/02/01 UR - http://ar.iiarjournals.org/content/32/2/687.abstract N2 - Aim: The impact of micronutrient intake and colorectal cancer (CRC) risk is poorly understood. The objective of this study was to evaluate the associations of selected micronutrients with risk of incident CRC in study participants from Newfoundland, Labrador (NL) and Ontario (ON), Canada. Materials and Methods: We conducted a population-based study among 1760 case participants and 2481 age- and sex-matched control participants. Information on diet and other lifestyle factors were measured using a food frequency questionnaire and a personal history questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, controlling for covariables. Results: Highest compared to lowest quartile intakes of certain micronutrients were associated with lower risk of CRC, including: calcium (from food and supplements (FS), OR=0.59; 95% CI=0.45-0.77, and from food only (FO): OR=0.76, 95% CI=0.59-0.97), vitamin C (FS:OR=0.67; 95%CI:0.51-0.88), vitamin D (FS: OR=0.73; 95% CI: 0.57-0.94, FO: OR=0.79, 95% CI=0.62-1.00), riboflavin (FS: OR=0.61; 95% CI=0.47-0.78, and folate (FS: OR=0.72; 95% CI=0.56-0.92). Higher risk of CRC was observed for iron intake (highest versus lowest quintiles: OR=1.34, 95% CI=1.01-1.78). Conclusion: This study presents evidence that dietary intake of calcium, vitamin D, vitamin C, riboflavin and folate are associated with a lower risk of incident CRC and that dietary intake of iron may be associated with a higher risk of the disease. ER -