TY - JOUR T1 - Comparison of Concurrent Chemoradiotherapy <em>versus</em> Induction Chemotherapy Followed by Radiation in Patients with Nasopharyngeal Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 681 LP - 686 VL - 32 IS - 2 AU - MASANORI KOMATSU AU - MAMORU TSUKUDA AU - HIDEKI MATSUDA AU - CHOICHI HORIUCHI AU - TAKAHIDE TAGUCH AU - MASAHIRO TAKAHASHI AU - GOHSHI NISHIMURA AU - MAKIKO MORI AU - TATUO NIHO AU - JUNICHI ISHITOYA AU - YASUNORI SAKUMA AU - MARIKO HIRAMA AU - OSAMU SHIONO Y1 - 2012/02/01 UR - http://ar.iiarjournals.org/content/32/2/681.abstract N2 - Purpose: The study aimed to evaluate the efficacy of concurrent chemoradiotherapy (CCRT) with platinum-based chemotherapy as a primary treatment for nasopharyngeal carcinoma (NPC) and to further compare the results of CCRT with these of neoadjuvant chemotherapy (NAC) followed by radiotherapy (RT). Patients and Methods: Before 1998, 21 patients with NPC received NAC followed by RT (NAC-RT). Between 1999 and 2008, a total of 25 NPC patients received CCRT. The CCRT group received a regimen including docetaxel (50 mg/m2, day1), cisplatin (CDDP, 60 mg/m2, day4) and continuous 5-fluorouracil (5-FU) infusion (600 mg/m2, day 1-5), the TPF regimen, or a regimen including CDDP (60 mg/m2, day4), continuous 5-FU infusion (600 mg/m2, day 1-5), methotrexate (MTX, 30 mg/m2, day 1) and leucovorin (LV, 20 mg/m2, day 1-5), PFML regimen. The CCRT group received 2 cycles of chemotherapy during definitive RT. The NAC group of patients received a PFML regimen. Results: The overall response rate after CCRT was 96%. The 3-year and 5-year disease-specific survival rates were 75.6% and 60.1%, respectively. In patients receiving NAC-RT, the 3-year and 5-year disease-specific survival rates were 84.1% and 67.3%, respectively. There was no difference observed in terms of survival rates between the group receiving CCRT and that receiving NAC-RT. Conclusion: CCRT with the TPF or PFML regimen was tolerable, and the NPC patients receiving this treatment showed excellent survival rates. In comparison to the group receiving NAC-RT, CCRT had no advantage in terms of the survival rate. In the future, the control of distant metastasis might play an important role in improving the survival rate of patients with advanced NPC receiving CCRT. ER -