RT Journal Article
SR Electronic
T1 The Effect of Radiotherapy on Implant-based Breast Reconstruction in the Setting of Skin-sparing Mastectomy: Clinical Series and Review of Complications
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 553
OP 557
VO 32
IS 2
A1 HUGHES, KENNETH
A1 BROWN, CHARLES
A1 PEREZ, VICTOR
A1 TING, JEANNETTE W.C.
A1 ROZEN, WARREN M.
A1 WHITAKER, IAIN S.
A1 KORENTAGER, RICHARD
YR 2012
UL http://ar.iiarjournals.org/content/32/2/553.abstract
AB Background: With the increasing popularity of skin–sparing mastectomy techniques, implant-based breast reconstruction and use of perioperative radiation therapy, there is a growing need to scrutinize the effects they have on breast reconstruction. This study examined the effect of radiation on implant-based breast reconstruction in patients who had skin-sparing or conventional mastectomies in terms of complication, reoperation, and capsular contracture rates. Patients and Methods: A retrospective review of 227 implant-based breast reconstructions in 132 mastectomy patients by a single surgeon was undertaken. All cases occurred over a four-year period (2006-2009) at a single institution. Complication, re-operation, and capsular contracture rates were tabulated against immediate and delayed reconstruction, skin-sparing and conventional mastectomy implant-based reconstruction, and irradiated and non-irradiated groups. Chi-square test was performed for statistical analysis. Results: The overall complication and reoperation rates of 15% and 10% in these 227 reconstructions compare favorably to reviewed series. Delayed reconstruction, skin-sparing mastectomy and irradiation were all associated with a significantly increased rate of re-operation, but not to an increase in complication or capsular contracture rates. Conclusion: The results of this study were more favourable than those of similar studies reported in the current literature, suggesting an increased role for implant-based reconstruction in the setting of adjuvant radiotherapy for patients that undergo skin-sparing mastectomy.