RT Journal Article
SR Electronic
T1 Cytotoxicity of Hydrophylic Silver Carboxylato Complexes
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 519
OP 522
VO 32
IS 2
A1 ELEANOR FOURIE
A1 ELIZABETH ERASMUS
A1 JANNIE C. SWARTS
A1 ANDRÉ TUCHSCHERER
A1 ALEXANDER JAKOB
A1 HEINRICH LANG
A1 GISELA K. JOONE
A1 CONSTANCE E.J. VAN RENSBURG
YR 2012
UL http://ar.iiarjournals.org/content/32/2/519.abstract
AB Background: Gold(I) and platinum(II) d10 and d8 electronic complexes such as (Au(PPh2CH2CH2PPh2)2)Cl and cisplatin, ((H3N)2PtCl2), possess strong antineoplastic activities. Almost no information is available regarding the anticancer activity of isoelectronic silver(I) d10 complexes. This study examined the cytotoxicity of stable water-soluble silver(I) carboxylates. The results were related to the cytotoxicity of cisplatin and (Au(PPh2CH2CH2PPh2)2)Cl. Materials and Methods: The silver carboxylates (AgO2CCH2OCH3), 1, (AgO2C-CH2OCH2CH2OCH3), 2, and (AgO2CCH2OCH2CH2OCH2CH2OCH3), 3, were investigated. Cytotoxicity tests were performed on the HeLa (human cervix epitheloid) cancer cell line, resting lymphocytes and PHA (phytohaemagglutinin)-stimulated lymphocyte cultures. Cell survival was measured by means of the colorometric 3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium bromide (MTT) assay. Results: The IC50 (50% cell growth inhibition) values of 1-3 in the HeLa cells varied between 2.6 and 6.1 μmol dm−3 with being 1 the most cytotoxic silver complex. Drug activity was inversely proportional to the length of the carboxylato chain length. Complexes 1-3 were 3-5 times more cytotoxic against the HeLa cancer cells than against the PHA stimulated lymphocyte cultures. Conclusion: A drug activity-structure relationship exists in that short-chain silver carboxylates are more cytotoxic than long-chain silver carboxylates, but silver d10 complexes are one order of magnitude less cytotoxic than platinum(II) d8 or gold(I) d10 complexes.