PT  - JOURNAL ARTICLE
AU  - DAISUKE SAWADA
AU  - TOMOYUKI KATAYAMA
AU  - YUYA TSUKUDA
AU  - NOZOMI SAITO
AU  - HIROSHI SAITO
AU  - SHINJI KAKUDA
AU  - MIDORI TAKIMOTO-KAMIMURA
AU  - KAZUYA TAKENOUCHI
AU  - ATSUSHI KITTAKA
TI  - The Difference between 14-<em>Epi</em>-previtamin D<sub>3</sub> and 14-<em>Epi</em>-19-norprevitamin D<sub>3</sub>: Their Synthesis and Binding Affinity for Human VDR
DP  - 2012 Jan 01
TA  - Anticancer Research
PG  - 319--326
VI  - 32
IP  - 1
4099  - http://ar.iiarjournals.org/content/32/1/319.short
4100  - http://ar.iiarjournals.org/content/32/1/319.full
SO  - Anticancer Res2012 Jan 01; 32
AB  - The synthesis of 14-epi-1α,25(OH)2previtamin D3, 14-epi-19-nor-1α,25(OH)2previtamin D3, and their 2-substituted analogs is described. The vitamin D receptor (VDR) binding affinity was further evaluated and 2α-methyl substituted 14-epi-1α,25(OH)2previtamin D3 had 17-fold more potent affinity than 14-epi-1α,25(OH)2previtamin D3.In the comparison of these compounds, the effects of thermal equilibrium, with or without 19-carbon at the A-ring, and their CD-ring structures are discussed.