RT Journal Article SR Electronic T1 PCA3 Score vs PSA Free/Total Accuracy in Prostate Cancer Diagnosis at Repeat Saturation Biopsy JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4445 OP 4449 VO 31 IS 12 A1 PIETRO PEPE A1 FRANCESCO ARAGONA YR 2011 UL http://ar.iiarjournals.org/content/31/12/4445.abstract AB Aim. PCA3 score and PSA free/total (F/T) accuracy in PCa diagnosis at repeat saturation prostate biopsy (SPBx) in patients with PSA between 4 and 10 ng/mL was evaluated. Materials and Methods: From October 2009 to September 2011 74 men (median 64 years) with persistent high or increasing PSA values, negative DRE, median PSA values of 8.9 ng/mL and primary negative extended biopsy underwent a SPBx (median 28 cores) for persistent suspicion for PCa. Results: PCA3 >20 and >35, PSA F/T ≤15%, ≤20% and ≤25% identified 25, 21, 18, 23 and 26 out 27 cancer, respectively. PCA3 cut-off of 20 demonstrated the best accuracy with an AUC-ROC curve of 0.73. Conclusion: The NPV equal to 88.9% suggests to use PCA3 cut-off 20 as an exclusion tool; moreover, PCA3 cut-off of 35 combined with PSA F/T ≤15% allows to spare 32.4% of unnecessary repeat biopsies.