RT Journal Article
SR Electronic
T1 Resveratrol Reduces TNF-α-induced U373MG Human Glioma Cell Invasion through Regulating NF-κB Activation and uPA/uPAR Expression
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4223
OP 4230
VO 31
IS 12
A1 JINHYUN RYU
A1 BO MI KU
A1 YEON KYUNG LEE
A1 JOO YEON JEONG
A1 SEOKMIN KANG
A1 JUNGIL CHOI
A1 YEONGAE YANG
A1 DONG HOON LEE
A1 GU SEOB ROH
A1 HYUN JOON KIM
A1 GYEONG JAE CHO
A1 WAN SUNG CHOI
A1 NAYOUNG KIM
A1 SANG SOO KANG
YR 2011
UL http://ar.iiarjournals.org/content/31/12/4223.abstract
AB Background: High invasiveness of glioma cells is one of the reasons that patients with malignant glioma have a poor prognosis. Resveratrol, a plant compound abundant in the peel of grapes, has been suggested as a potential cancer chemopreventive agent. Therefore, we investigated the effect of resveratrol on glioma cell invasion. Materials and Methods: The effect of resveratrol on U373MG human glioma cell invasion was assessed by Matrigel assay and methylthiazoltetrazolium assay. Western blotting and reverse transcription-polymerase chain reaction were performed to elucidate the action mechanism of resveratrol. Results: Resveratrol reduced tumor necrosis factor (TNF)-α-induced U373MG human glioma cell invasion. In addition, resveratrol repressed nuclear factor kappa B (NF-κB) activation and down-regulated mRNA expression of urokinase plasminogen activator (uPA) and its receptor in TNF-α-treated glioma cells. Conclusion: These findings suggest that resveratrol could prevent glioma cell invasion via inhibiting proteolysis of extracellular matrix.