TY - JOUR T1 - Resveratrol Reduces TNF-α-induced U373MG Human Glioma Cell Invasion through Regulating NF-κB Activation and uPA/uPAR Expression JF - Anticancer Research JO - Anticancer Res SP - 4223 LP - 4230 VL - 31 IS - 12 AU - JINHYUN RYU AU - BO MI KU AU - YEON KYUNG LEE AU - JOO YEON JEONG AU - SEOKMIN KANG AU - JUNGIL CHOI AU - YEONGAE YANG AU - DONG HOON LEE AU - GU SEOB ROH AU - HYUN JOON KIM AU - GYEONG JAE CHO AU - WAN SUNG CHOI AU - NAYOUNG KIM AU - SANG SOO KANG Y1 - 2011/12/01 UR - http://ar.iiarjournals.org/content/31/12/4223.abstract N2 - Background: High invasiveness of glioma cells is one of the reasons that patients with malignant glioma have a poor prognosis. Resveratrol, a plant compound abundant in the peel of grapes, has been suggested as a potential cancer chemopreventive agent. Therefore, we investigated the effect of resveratrol on glioma cell invasion. Materials and Methods: The effect of resveratrol on U373MG human glioma cell invasion was assessed by Matrigel assay and methylthiazoltetrazolium assay. Western blotting and reverse transcription-polymerase chain reaction were performed to elucidate the action mechanism of resveratrol. Results: Resveratrol reduced tumor necrosis factor (TNF)-α-induced U373MG human glioma cell invasion. In addition, resveratrol repressed nuclear factor kappa B (NF-κB) activation and down-regulated mRNA expression of urokinase plasminogen activator (uPA) and its receptor in TNF-α-treated glioma cells. Conclusion: These findings suggest that resveratrol could prevent glioma cell invasion via inhibiting proteolysis of extracellular matrix. ER -