RT Journal Article
SR Electronic
T1 First Study of Oral Artenimol-R in Advanced Cervical Cancer: Clinical Benefit, Tolerability and Tumor Markers
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4417
OP 4422
VO 31
IS 12
A1 FRANS HERWIG JANSEN
A1 INNOCENT ADOUBI
A1 KOUASSI COMOE J.C
A1 TINNE DE CNODDER
A1 NICOLAS JANSEN
A1 ALEXANDER TSCHULAKOW
A1 THOMAS EFFERTH
YR 2011
UL http://ar.iiarjournals.org/content/31/12/4417.abstract
AB Background/Aim: Artenimol-R is cytotoxic in transformed cervical cells and safety in humans is yet to be established. The present study investigates the clinical benefits, safety and the tumor marker effect of orally administered Artenimol-R in patients with advanced cervix carcinoma. Patients and Methods: Ten patients were treated with Artenimol-R for 28 days. Clinical symptoms, vaginal discharge and pain were followed-up. Adverse events were recorded. Biopsy samples were analyzed by immunohistochemistry for the expression of relevant tumor markers. Results: Artenimol-R treatment induced clinical remission with a median time for the disappearance of the symptoms being 7 days. No adverse events of grade 3 or 4 occurred. The expression of p53, Epidermal growth factor receptor (EGFR), and antigen Ki-67 as a cellular marker of proliferation, as well as the number of blood vessels stained by the CD31 antibody decreased, whereas the expression of transferrin receptor protein 1 (CD71) increased. Conclusion: The current pilot study provides evidence on the improvement of the clinical symptoms and the good tolerability of Artenimol-R in patients with advanced carcinoma of the cervix uteri. A survival trial with Artenimol-R in advanced patients is warranted.