PT - JOURNAL ARTICLE AU - YUKARI MIYOSHI AU - YUTAKA UEDA AU - AKIKO MORIMOTO AU - TAKUHEI YOKOYAMA AU - SHINYA MATSUZAKI AU - EIJI KOBAYASHI AU - TOSHIHIRO KIMURA AU - KIYOSHI YOSHINO AU - MASAMI FUJITA AU - TAKAYUKI ENOMOTO AU - TADASHI KIMURA TI - Salvage Chemotherapy for Ovarian Carcinoma Recurring During or After Consolidation Chemotherapy with Paclitaxel DP - 2011 Dec 01 TA - Anticancer Research PG - 4613--4617 VI - 31 IP - 12 4099 - http://ar.iiarjournals.org/content/31/12/4613.short 4100 - http://ar.iiarjournals.org/content/31/12/4613.full SO - Anticancer Res2011 Dec 01; 31 AB - Background: The aim of the study was to analyze the effectiveness of salvage chemotherapy for recurring ovarian carcinoma during or after consolidation chemotherapy. Patients and Methods: During the study period, 12 patients received salvage chemotherapy for recurrence during or after consolidation chemotherapy. These cases were retrospectively reviewed. Results: The response rate for salvage chemotherapy was 67% and was significantly associated with treatment-free interval (TFI) after consolidation (p=0.038). Progression-free survival was also significantly related to TFI (p=0.032). Combination chemotherapy of cisplatin plus irinotecan was effective in all five cases with TFI≥6 months and in three out of seven cases with TFI<6 months. Conclusion: Our study provides, for the first time, evidence that effectiveness of salvage chemotherapy for recurrent ovarian carcinoma occurring during or after consolidation chemotherapy can be predicted by TFI, and that combination chemotherapy of cisplatin plus irinotecan is potentially useful for these cases.