PT - JOURNAL ARTICLE AU - E. CHEREAU AU - V. LAVOUE AU - M. BALLESTER AU - C. COUTANT AU - F. SELLE AU - A. CORTEZ AU - E. DARAÏ AU - J. LEVEQUE AU - R. ROUZIER TI - External Validation of a Laparoscopic-based Score to Evaluate Resectability for Patients with Advanced Ovarian Cancer Undergoing Interval Debulking Surgery DP - 2011 Dec 01 TA - Anticancer Research PG - 4469--4474 VI - 31 IP - 12 4099 - http://ar.iiarjournals.org/content/31/12/4469.short 4100 - http://ar.iiarjournals.org/content/31/12/4469.full SO - Anticancer Res2011 Dec 01; 31 AB - Aim: To evaluate the relevance of laparoscopic index of Fagotti et al during staging laparoscopy (S-LPS) to predict optimal cytoreduction during interval debulking surgery (IDS) after neoadjuvant chemotherapy for ovarian cancer. Patients and Methods: Fifty-two patients with stage III–IV ovarian cancer were retrospectively analyzed. We evaluated discrimination with a receiver operating characteristic (ROC) curve analysis and calibration of Fagotti et al's model among our population and compared this performance with their data. Results: A score >4 was associated with optimal resection with sensitivity and positive predictive value (PPV) of 95% and 82% respectively. The ROC curve analysis gave an area under the curve (AUC) of 0.72 (95% confidence interval (CI) 0.65-0.80) for our population compared to 0.88 (95% CI 0.84-0.91) in Fagotti et al's population. Percentages predicted in our population were unsatisfactory (p<0.01), illustrating the different rates of optimal cytoreduction between the centers (average error of 25%). Conclusion: The laparoscopic index of Fagotti et al is relevant in prediction of optimal cytoreduction among women undergoing IDS.