RT Journal Article SR Electronic T1 Feasibility of Image-guided Radiotherapy Based on Tomotherapy for the Treatment of Locally Advanced Anal Carcinoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4393 OP 4396 VO 31 IS 12 A1 NAM P. NGUYEN A1 JACQUELINE VOCK A1 THOMAS SROKA A1 RIHAN KHAN A1 SIYOUNG JANG A1 ALEXANDER CHI A1 MICHAEL BETZ A1 LARS EWELL A1 DEIRDRE COHEN A1 RICHARD P. VO A1 MELISSA MILLS A1 VINCENT VINH-HUNG YR 2011 UL http://ar.iiarjournals.org/content/31/12/4393.abstract AB Background: The standard of care for locally advanced anal cancer has been concurrent chemoradiation. However, conventional treatment with 3-dimensional radiotherapy is associated with significant toxicity. The feasibility of new radiotherapy techniques such as image-guided radiotherapy (IGRT) in combination with chemotherapy for the treatment of this malignancy was assessed. Patients and Methods: A retrospective review of five patients with locally advanced anal carcinoma treated with Tomotherapy-based IGRT was conducted. All the patients received concurrent chemotherapy. Results: Gastrointestinal toxicity remained the limiting factor as four patients experienced grade 3-4 enteritis requiring a break during treatment. No patient experienced grade 3-4 hematological toxicity. Despite the large tumor size, three patients achieved local control at a median follow-up of 19 months. Conclusion: Tomotherapy-based IGRT may be a promising treatment for locally advanced anal cancer and needs to be investigated in further prospective trials.