TY - JOUR T1 - Feasibility of Image-guided Radiotherapy Based on Tomotherapy for the Treatment of Locally Advanced Anal Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 4393 LP - 4396 VL - 31 IS - 12 AU - NAM P. NGUYEN AU - JACQUELINE VOCK AU - THOMAS SROKA AU - RIHAN KHAN AU - SIYOUNG JANG AU - ALEXANDER CHI AU - MICHAEL BETZ AU - LARS EWELL AU - DEIRDRE COHEN AU - RICHARD P. VO AU - MELISSA MILLS AU - VINCENT VINH-HUNG Y1 - 2011/12/01 UR - http://ar.iiarjournals.org/content/31/12/4393.abstract N2 - Background: The standard of care for locally advanced anal cancer has been concurrent chemoradiation. However, conventional treatment with 3-dimensional radiotherapy is associated with significant toxicity. The feasibility of new radiotherapy techniques such as image-guided radiotherapy (IGRT) in combination with chemotherapy for the treatment of this malignancy was assessed. Patients and Methods: A retrospective review of five patients with locally advanced anal carcinoma treated with Tomotherapy-based IGRT was conducted. All the patients received concurrent chemotherapy. Results: Gastrointestinal toxicity remained the limiting factor as four patients experienced grade 3-4 enteritis requiring a break during treatment. No patient experienced grade 3-4 hematological toxicity. Despite the large tumor size, three patients achieved local control at a median follow-up of 19 months. Conclusion: Tomotherapy-based IGRT may be a promising treatment for locally advanced anal cancer and needs to be investigated in further prospective trials. ER -