RT Journal Article
SR Electronic
T1 3D Breast Ultrasound: A Significant Predictor in Breast Cancer Reduction under Pre-operative Chemotherapy
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4039
OP 4042
VO 31
IS 11
A1 WARM, MATHIAS
A1 DUDA, VOLKER
A1 EICHLER, CHRISTIAN
A1 HARBECK, NADIA
A1 GOSSMANN, AXEL
A1 THOMAS, ANKE
A1 HOOPMANN, MARKUS
A1 OHLINGER, RALF
A1 BREIDENBACH, MARTINA
A1 KATES, RONALD E.
YR 2011
UL http://ar.iiarjournals.org/content/31/11/4039.abstract
AB Background: The objective was the investigation of a possible predictive quantitative impact of initial tumor sphericity, measured by 3D sonography, on response to pre-operative chemotherapy. Patients and Methods: This 3D ultrasound study was conducted on 41 consecutive primary breast cancer patients who received pre-operative epirubicin and paclitaxel chemotherapy; the tumors were measured by 3D sonography and by pathology after chemotherapy. Sphericity was defined as the ratio of the smallest to the largest extent by 3D sonography. Results: A predictive impact of initial tumor sphericity on response to pre-operative chemotherapy was quantitatively identified for the first time. Sphericity was a significant predictor of pathological complete remission with a rank difference of 0.34 or about 1/3 i.e., spherical tumors were more likely to show successful remission. Conclusion: Tumor sphericity as defined from 3D sonography could be predictive of response to pre-operative chemotherapy regimens; prospective investigation is suggested.