PT  - JOURNAL ARTICLE
AU  - WARM, MATHIAS
AU  - DUDA, VOLKER
AU  - EICHLER, CHRISTIAN
AU  - HARBECK, NADIA
AU  - GOSSMANN, AXEL
AU  - THOMAS, ANKE
AU  - HOOPMANN, MARKUS
AU  - OHLINGER, RALF
AU  - BREIDENBACH, MARTINA
AU  - KATES, RONALD E.
TI  - 3D Breast Ultrasound: A Significant Predictor in Breast Cancer Reduction under Pre-operative Chemotherapy
DP  - 2011 Nov 01
TA  - Anticancer Research
PG  - 4039--4042
VI  - 31
IP  - 11
4099  - http://ar.iiarjournals.org/content/31/11/4039.short
4100  - http://ar.iiarjournals.org/content/31/11/4039.full
SO  - Anticancer Res2011 Nov 01; 31
AB  - Background: The objective was the investigation of a possible predictive quantitative impact of initial tumor sphericity, measured by 3D sonography, on response to pre-operative chemotherapy. Patients and Methods: This 3D ultrasound study was conducted on 41 consecutive primary breast cancer patients who received pre-operative epirubicin and paclitaxel chemotherapy; the tumors were measured by 3D sonography and by pathology after chemotherapy. Sphericity was defined as the ratio of the smallest to the largest extent by 3D sonography. Results: A predictive impact of initial tumor sphericity on response to pre-operative chemotherapy was quantitatively identified for the first time. Sphericity was a significant predictor of pathological complete remission with a rank difference of 0.34 or about 1/3 i.e., spherical tumors were more likely to show successful remission. Conclusion: Tumor sphericity as defined from 3D sonography could be predictive of response to pre-operative chemotherapy regimens; prospective investigation is suggested.