<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">WARM, MATHIAS</style></author><author><style face="normal" font="default" size="100%">DUDA, VOLKER</style></author><author><style face="normal" font="default" size="100%">EICHLER, CHRISTIAN</style></author><author><style face="normal" font="default" size="100%">HARBECK, NADIA</style></author><author><style face="normal" font="default" size="100%">GOSSMANN, AXEL</style></author><author><style face="normal" font="default" size="100%">THOMAS, ANKE</style></author><author><style face="normal" font="default" size="100%">HOOPMANN, MARKUS</style></author><author><style face="normal" font="default" size="100%">OHLINGER, RALF</style></author><author><style face="normal" font="default" size="100%">BREIDENBACH, MARTINA</style></author><author><style face="normal" font="default" size="100%">KATES, RONALD E.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">3D Breast Ultrasound: A Significant Predictor in Breast Cancer Reduction under Pre-operative Chemotherapy</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011-11-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4039-4042</style></pages><volume><style face="normal" font="default" size="100%">31</style></volume><issue><style face="normal" font="default" size="100%">11</style></issue><abstract><style  face="normal" font="default" size="100%">Background: The objective was the investigation of a possible predictive quantitative impact of initial tumor sphericity, measured by 3D sonography, on response to pre-operative chemotherapy. Patients and Methods: This 3D ultrasound study was conducted on 41 consecutive primary breast cancer patients who received pre-operative epirubicin and paclitaxel chemotherapy; the tumors were measured by 3D sonography and by pathology after chemotherapy. Sphericity was defined as the ratio of the smallest to the largest extent by 3D sonography. Results: A predictive impact of initial tumor sphericity on response to pre-operative chemotherapy was quantitatively identified for the first time. Sphericity was a significant predictor of pathological complete remission with a rank difference of 0.34 or about 1/3 i.e., spherical tumors were more likely to show successful remission. Conclusion: Tumor sphericity as defined from 3D sonography could be predictive of response to pre-operative chemotherapy regimens; prospective investigation is suggested.</style></abstract></record></records></xml>