RT Journal Article
SR Electronic
T1 Cryotreatment against Metastatic Renal Cell Bone Tumour Reduced Multiple Lung Metastases
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2927
OP 2930
VO 31
IS 9
A1 HIDEJI NISHIDA
A1 TOSHIHARU SHIRAI
A1 KATSUHIRO HAYASHI
A1 AKIHIKO TAKEUCHI
A1 YOSHIKAZU TANZAWA
A1 ATSUSHI MIZOKAMI
A1 MIKIO NAMIKI
A1 HIROYUKI TSUCHIYA
YR 2011
UL http://ar.iiarjournals.org/content/31/9/2927.abstract
AB Metastatic renal cell carcinoma (RCC) has a poor response to anticancer chemotherapy and radiotherapy. While immunotherapy and molecular targeted drugs have been used as first-line therapy for RCC metastasis, the response rate to these agents is low. We report the case of a patient with lung and bone metastases of RCC whose lung metastases disappeared after reconstruction using the resected specimen treated by liquid nitrogen for the bone metastasis. This 60-year-old female had a left RCC with multiple lung metastases and a left femoral bone metastasis at the time of diagnosis. After left nephrectomy followed by immunotherapy, we performed tumour excision and reconstruction with frozen recycled autograft. The lung metastases had disappeared by 10 months after surgery, while serum levels of interferon-gamma and interleukin-12 had increased. We postulate that the antitumour activity resulted from immunotherapy plus cryotreatment of her bone metastasis and believe that this case supports continued research into immunotherapy for cancer.