RT Journal Article
SR Electronic
T1 Elevated YB-1 Expression is a New Unfavorable Prognostic Factor in Non-Hodgkin's Lymphomas
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2963
OP 2970
VO 31
IS 9
A1 KATARZYNA SZCZURASZEK
A1 AGNIESZKA HALON
A1 VERENA MATERNA
A1 GRZEGORZ MAZUR
A1 TOMASZ WROBEL
A1 KAZIMIERZ KULICZKOWSKI
A1 PIOTR DONIZY
A1 PER S. HOLM
A1 HERMANN LAGE
A1 PAWEL SUROWIAK
YR 2011
UL http://ar.iiarjournals.org/content/31/9/2963.abstract
AB Background: Y-Box-binding protein-1 (YB-1) acts as a transcription factor for multiple genes and is linked to DNA replication and repair, cell proliferation and resistance to cytostatic drugs. Patients and Methods: The prognostic value of YB-1 expression in primarily untreated malignant non-Hodgkin's lymphomas (NHLs) was examined using immunohistochemistry. Results: Expression of YB-1 was detected in 48 out of 56 NHLs, and the immunohistochemical reaction was localized exclusively in the cytoplasm. Expression of YB-1 did not correlate with clinicopathological variables. Patients with higher YB-1 expression had shorter progression-free survival during the entire period of observation (p=0.0434), as well as in the course of 30 months' observation (p=0.0253). Additionally, in the course of 50 months' observation, patients with higher expression of YB-1 demonstrated a shorter overall survival time (p=0.0383) and a shorter progression-free survival (p=0.0309). Conclusion: Elevated YB-1 expression may represent a new unfavorable prognostic factor.