PT  - JOURNAL ARTICLE
AU  - ICHITAROU SHIRATSUCHI
AU  - YOSHITO AKAGI
AU  - AKIHIKO KAWAHARA
AU  - TETSUSHI KINUGASA
AU  - KANSAKAR ROMEO
AU  - TAKEFUMI YOSHIDA
AU  - YASUHIKO RYU
AU  - YUKITO GOTANDA
AU  - MASAYOSHI KAGE
AU  - KAZUO SHIROUZU
TI  - Expression of IGF-1 and IGF-1R and Their Relation to Clinicopathological Factors in Colorectal Cancer
DP  - 2011 Jul 01
TA  - Anticancer Research
PG  - 2541--2545
VI  - 31
IP  - 7
4099  - http://ar.iiarjournals.org/content/31/7/2541.short
4100  - http://ar.iiarjournals.org/content/31/7/2541.full
SO  - Anticancer Res2011 Jul 01; 31
AB  - Background: Expression of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) has been shown to increase in colorectal cancer. We examined the correlation between expression of IGF-1 and IGF-1R and clinicopathological factors in colorectal cancer. Patients and Methods: A prospective study was conducted of 210 colorectal cancer patients that underwent resection from January 2002 to December 2004. The clinicopathological data was correlated to expression of IGF-1 and IGF-1R obtained from immunohistochemical analysis. Statistical analysis was carried using univariate and multivariate analysis. Results: IGF1 and IGF-1R staining was positive in 169 (80%) and 139 (66%) cases, respectively. Univariate and multivariate analyses showed significant correlation between expression of IGF-1 and tumor size (p=0.0024), and depth of invasion (p=0.0147). While IGF-1R was significantly correlated to tumor size and depth of invasion in univariate analysis, only tumor size (p=0.0658) had a strong association in multivariate analysis. Conclusion: Expression of IGF-1 and IGF-1R seems to increase with tumor size in colorectal cancer.