TY - JOUR T1 - Expression of IGF-1 and IGF-1R and Their Relation to Clinicopathological Factors in Colorectal Cancer JF - Anticancer Research JO - Anticancer Res SP - 2541 LP - 2545 VL - 31 IS - 7 AU - ICHITAROU SHIRATSUCHI AU - YOSHITO AKAGI AU - AKIHIKO KAWAHARA AU - TETSUSHI KINUGASA AU - KANSAKAR ROMEO AU - TAKEFUMI YOSHIDA AU - YASUHIKO RYU AU - YUKITO GOTANDA AU - MASAYOSHI KAGE AU - KAZUO SHIROUZU Y1 - 2011/07/01 UR - http://ar.iiarjournals.org/content/31/7/2541.abstract N2 - Background: Expression of insulin-like growth factor-1 (IGF-1) and IGF-1 receptor (IGF-1R) has been shown to increase in colorectal cancer. We examined the correlation between expression of IGF-1 and IGF-1R and clinicopathological factors in colorectal cancer. Patients and Methods: A prospective study was conducted of 210 colorectal cancer patients that underwent resection from January 2002 to December 2004. The clinicopathological data was correlated to expression of IGF-1 and IGF-1R obtained from immunohistochemical analysis. Statistical analysis was carried using univariate and multivariate analysis. Results: IGF1 and IGF-1R staining was positive in 169 (80%) and 139 (66%) cases, respectively. Univariate and multivariate analyses showed significant correlation between expression of IGF-1 and tumor size (p=0.0024), and depth of invasion (p=0.0147). While IGF-1R was significantly correlated to tumor size and depth of invasion in univariate analysis, only tumor size (p=0.0658) had a strong association in multivariate analysis. Conclusion: Expression of IGF-1 and IGF-1R seems to increase with tumor size in colorectal cancer. ER -