TY - JOUR T1 - Phase II Trial of Adjuvant Chemotherapy with Bi-Weekly Carboplatin Plus Paclitaxel in Patients with Completely Resected Non-small Cell Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 3039 LP - 3044 VL - 30 IS - 7 AU - MASAKAZU SUGAYA AU - HIDETAKA URAMOTO AU - AKIHIKO UCHIYAMA AU - AKIRA NAGASHIMA AU - RYOICHI NAKANISHI AU - HISANOBU SAKATA AU - KOZO NAKANISHI AU - TAKESHI HANAGIRI AU - KOSEI YASUMOTO Y1 - 2010/07/01 UR - http://ar.iiarjournals.org/content/30/7/3039.abstract N2 - Background: Adjuvant chemotherapy improves the prognosis of patients with non-small cell lung cancer (NSCLC) after a complete resection despite unacceptable toxicity and low compliance. Methods: A total of 67 patients were enrolled in a multi-institutional study. The patients received chemotherapy with carboplatin (CBDCA) area under the curve of 3 and paclitaxel (PTX) 90 mg/m2 every 2 weeks for six cycles after surgery. Results: Fifty patients (74.6%) completed all cycles of therapy. The presence of grade 3 and 4 toxicities of neutropenia were 13.4, and 3.0%, respectively. Non-haematological adverse effects were infrequent and no treatment-related death was registered. The estimated disease-free survival and overall survival at 2 years were 89.0% and 88.8%, respectively. Conclusion: A bi-weekly schedule of CBDCA and PTX as adjuvant chemotherapy showed an acceptable toxicity and favourable feasibility in Japanese NSCLC patients after complete tumor resection. Consequently, it is desirable to validate this regimen in a future randomized clinical trial. ER -