RT Journal Article
SR Electronic
T1 <em>MACC1</em> as a Marker for Advanced Colorectal Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2689
OP 2692
VO 30
IS 7
A1 ATSUSHI SHIRAHATA
A1 KAZUKI SHINMURA
A1 YOUHEI KITAMURA
A1 KAZUMA SAKURABA
A1 KAZUAKI YOKOMIZO
A1 TETSUHIRO GOTO
A1 HIROKI MIZUKAMI
A1 MITSUO SAITO
A1 KAZUYOSHI ISHIBASHI
A1 GAKU KIGAWA
A1 HIROSHI NEMOTO
A1 KENJI HIBI
YR 2010
UL http://ar.iiarjournals.org/content/30/7/2689.abstract
AB Background: Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases. Patients and Methods: We analyzed MACC1 expression levels in 52 colorectal cancer samples using quantitative real-time polymerase chain reaction (QRT-PCR). Results: We found that MACC1 expression showed significant correlation with peritoneal dissemination (p=0.042) and higher stage of TNM classification (p=0.007). Conclusion: These results suggest that MACC1 is more frequently expressed in advanced colorectal carcinomas.