RT Journal Article
SR Electronic
T1 Psychological Response to Cancer: Role of 5-HTTLPR Genetic Polymorphism of Serotonin Transporter
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3823
OP 3826
VO 30
IS 9
A1 GIULIA SCHILLANI
A1 ELISABETTA MARTINIS
A1 MARIA ANNA CAPOZZO
A1 DANIEL ERA
A1 TANIA CRISTANTE
A1 GIORGIO MUSTACCHI
A1 MARIA ANNA CONTE
A1 MAURIZIO DE VANNA
A1 LUIGI GRASSI
A1 TULLIO GIRALDI
YR 2010
UL http://ar.iiarjournals.org/content/30/9/3823.abstract
AB Background: 5-HTTLPR genetic polymorphism of serotonin transporter (SERT) and stressful life events facilitate depression. The aim of this investigation was therefore to determine the correlations between SERT polymorphism and mental adjustement to cancer. Patients and Methods: Breast cancer patients early after surgery, and subjects with various advanced tumours were recruited, evaluated using the Mini Mental Adjustment to Cancer Scale and Hospital Anxiety and Depression Scale (HADS), and genotyped. Results: In early breast cancer patients (n=53), hopelessness-helplessness (HH) and anxious preoccupation (AP) significantly correlated with depression and anxiety; avoidance (AV) correlated with anxiety. Advanced cancer patients (n=73) displayed similar correlations, and a negative correlation of HADS depression with fighting spirit (FS) and AV. The stratification for 5-HTTLPR showed that early breast cancer carriers of the L/L variant displayed a significant correlation between HH and depression. Conclusion: Among early breast cancer patients, a specific set, characterized by their 5-HTTLPR variant, display differential correlations between HH and depression, with possible implications for treatment options.