PT  - JOURNAL ARTICLE
AU  - TSUNEHIRO TAKAHASHI
AU  - YOSHIRO SAIKAWA
AU  - HIROMASA TAKAISHI
AU  - HIROYA TAKEUCHI
AU  - NORIHITO WADA
AU  - TAKASHI OYAMA
AU  - RIEKO NAKAMURA
AU  - YUKO KITAGAWA
TI  - Feasibility and Efficacy of Combination Chemotherapy with S-1 and Fractional Cisplatin for Advanced Gastric Cancer
DP  - 2010 Sep 01
TA  - Anticancer Research
PG  - 3759--3762
VI  - 30
IP  - 9
4099  - http://ar.iiarjournals.org/content/30/9/3759.short
4100  - http://ar.iiarjournals.org/content/30/9/3759.full
SO  - Anticancer Res2010 Sep 01; 30
AB  - Background: There is a great need for effective outpatient chemotherapy for advanced gastric cancer in patients with good performance status. The present pilot study evaluated the use of combination chemotherapy with S-1 and fractional CDDP for unresectable–recurrent gastric cancer in an outpatient setting. Patients and Methods: A total of 41 patients with unresectable or recurrent gastric cancer were treated with this combination chemotherapy. S-1 was administered orally every day on days 1-28 and CDDP was infused on days 1, 15, and 29. Results: Thirty-six patients had measurable lesions and 19 patients had partial responses, resulting in an overall response rate of 52.8%. The median survival time was 494 days. There was no grade 4 haematological toxicity, no grade 3 or more non-haematological toxicity, and no treatment-related death. Conclusion: This combination chemotherapy has no serious toxicities in patients with unresectable and recurrent gastric cancer and can be used effectively in an outpatient setting.