TY - JOUR T1 - Expression of Metalloproteinases MMP-2 and MMP-9 in Sentinel Lymph Node and Serum of Patients with Metastatic and Non-Metastatic Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 3521 LP - 3527 VL - 30 IS - 9 AU - A. DANIELE AU - A.F. ZITO AU - G. GIANNELLI AU - R. DIVELLA AU - M. ASSELTI AU - A. MAZZOCCA AU - A. PARADISO AU - M. QUARANTA Y1 - 2010/09/01 UR - http://ar.iiarjournals.org/content/30/9/3521.abstract N2 - The objective of this study was to evaluate the expression of MMP-2 and MMP-9 in sentinel lymph node and serum of breast cancer patients in order to evaluate their clinical significance and usefulness as diagnostic tumour markers. Expression of MMP-2 and MMP-9 was performed on sentinel lymph node by immunohistochemistry while gelatine zymography was used to determinate the serum expression. The association of gelatinases with clinicopathological features, were analysed. Metastatic and non-metastatic breast cancer patients and 34 healthy women were involved. Gelatinases expression were significantly higher in metastatic breast cancer in comparison to non-metastatic cancer and the control group both in the sentinel lymph node and serum. Results showed a statistically significant correlation between MMP-2 or MMP-9 and cancer familiality, MMP-9 and CA 15.3 levels, and MMP-9 and grading. This study suggests a clinical utility of these proteolytic markers in malignant tumour, growth, invasion and metastasis in breast cancer. ER -