@article {DEEB3333, author = {D. DEEB and X. GAO and H. JIANG and A.S. ARBAB and S.A. DULCHAVSKY and S.C. GAUTAM}, title = {Growth Inhibitory and Apoptosis-inducing Effects of Xanthohumol, a Prenylated Chalone Present in Hops, in Human Prostate Cancer Cells}, volume = {30}, number = {9}, pages = {3333--3339}, year = {2010}, publisher = {International Institute of Anticancer Research}, abstract = {Promotion of apoptosis in cancer cells could potentially lead to the regression and improved prognosis of hormone-refractory prostate cancer. Xanthohumol (XN), a prenylated chalcone-derived from hops, has shown strong antitumorigenic activity towards diverse types of cancer cells. In the present study, the growth-inhibitory and apoptosis-inducing activity of XN was tested in hormone-sensitive and hormone-refractory human prostate cancer cells lines. Cell growth/viability assay (MTS) demonstrated that prostate cancer cells are highly sensitive to XN at a concentration range of 20-40 μM. The primary mode of tumor cell destruction was apoptosis as demonstrated by the binding of annexin V-FITC, cleavage of PARP-1, activation of procaspases -3, -8, and -9, mitochondrial depolarization and release of cytochrome c from mitochondria. Induction of apoptosis by XN was associated with the inhibition of prosurvival Akt, NF-κB and mTOR signaling proteins and NF-κB-regulated anti-apoptotic Bcl-2 and survivin. These studies provide a rationale for clinical evaluation of XN for the treatment of hormone-refractory metastatic prostate cancer.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/30/9/3333}, eprint = {https://ar.iiarjournals.org/content/30/9/3333.full.pdf}, journal = {Anticancer Research} }