RT Journal Article
SR Electronic
T1 Lack of Prognostic Value of Topoisomerase II Alpha in Patients with Breast Cancer: Analysis with Tissue Microarray
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2459
OP 2462
VO 30
IS 6
A1 SHEEN-CHEN, SHYR-MING
A1 HUANG, CHUN-YING
A1 ZHANG, HAO
A1 HUANG, CHAO-CHENG
A1 TANG, REI-PING
YR 2010
UL http://ar.iiarjournals.org/content/30/6/2459.abstract
AB Background: The creation of a tissue microarray (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study applied TMA in order to analyse the topoisomerase II alpha status in breast cancer and to elucidate its relationship in breast cancer biology. Patients and Methods: Archived tissue specimens from 94 patients with primary invasive breast cancer were selected and the topoisomerase II alpha expression was analysed by TMA. Data concerning age, oestrogen receptor status, histological grading and TNM staging were also collected. Results: There were 20 patients (21.3%) with 1+ expression in topoisomerase II alpha, 33 patients (35.1%) with 2+ expression and 41 patients (43.6%) with 3+ expression. By multivariate analysis, oestrogen receptor status, histological grading and TNM staging were found to be significantly related to the overall five-year survival rate. Conclusion: Topoisomerase II alpha expression failed to demonstrate prognostic value in patients with breast cancer.