@article {RUBIO2419, author = {CARLOS A. RUBIO and JON G. J{\'O}NASSON and GABRIELLA NESI and JOANNA MAZUR and EL{\'I}NBORG {\'O}LAFSD{\'O}TTIR}, title = {The Size of Colon Polyps Revisited: Intra- and Inter-observer Variations}, volume = {30}, number = {6}, pages = {2419--2423}, year = {2010}, publisher = {International Institute of Anticancer Research}, abstract = {Background: It has been postulated that the occurrence of invasive carcinoma in a colon adenoma can be predicted by estimating the size of the resected polyp. Recently, significant intra- and inter-observer differences in size were found when 22 pathologists estimated the size of 12 polyp phantoms. In this work, the size of a large cohort of endoscopically-resected colon polyps was assessed with a novel method. Patients and Methods: Three pathologists measured photocopies of 148 resected polyps (adenomas at histology) in two independent trials. Results: The size recorded by the three participants was congruent in only 50\% of the measurements in trial 1, and in 62\% in trial 2. A significant difference in size asessment was found between the three investigators (p<=0.05). When 6 possible combinations (the 3 size limits proposed for predicting cancer risk in adenomas, and 2 different trials) were tested for the 13 adenomas showing invasive carcinoma, merely one of the three participants recorded the same size, but only in 11\% of the 6 possible combinations. Conclusion: Present and previous investigations indicate that the lack of reproducibility makes the use of size limits in predicting cancer risk in polyps removed at colonoscopy unreliable.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/30/6/2419}, eprint = {https://ar.iiarjournals.org/content/30/6/2419.full.pdf}, journal = {Anticancer Research} }