RT Journal Article
SR Electronic
T1 Therapeutic Effects of Hybrid Liposomes on Gastric Carcinoma Involve Apoptosis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2011
OP 2016
VO 30
IS 6
A1 ICHIHARA, HIDEAKI
A1 MATSUOKA, YUSUKE
A1 MATSUMOTO, YOKO
A1 UEOKA, RYUICHI
YR 2010
UL http://ar.iiarjournals.org/content/30/6/2011.abstract
AB Hybrid liposomes (HLs) composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(23)dodecyl ether (C12(EO)23), having a hydrodynamic diameter under 100 nm, were preserved for a period of one month. The inhibitory effects of HLs on the growth of gastric carcinoma (CoRa 622 G6) cells in vitro were investigated. Decrease in mitochondrial membrane potential and activation of caspase-8, caspase-9 and caspase-3 were observed, indicating that apoptotic signals induced by HLs should pass through mitochondria and these caspases. Remarkable inhibitory effects on the metastasis of gastric carcinoma along with apoptosis and prolonged survival were obtained for mouse models of gastric carcinoma with peritoneal dissemination after the treatment with HLs in vivo.