RT Journal Article
SR Electronic
T1 Usefulness of Combined FDG-PET with CT or Tumour Markers in Lung Cancer Diagnosis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1741
OP 1745
VO 30
IS 5
A1 KONSTANTIN KLEY
A1 PETER OEHR
YR 2010
UL http://ar.iiarjournals.org/content/30/5/1741.abstract
AB Background: The synergy between in vitro and in vivo imaging was investigated in this study. Patients and Methods: Comparison of fluorodeoxyglucose positron-emission tomography (FDG-PET) and computerised tomography (CT) included 62 patients (group 1), while that for comparison of FDG-PET and serum tumour markers included 26 patients (group 2). Results: In group1, FDG-PET had positive and negative predictive values of 81% and 80% respectively, compared to 73.7% and 71.4% for CT, respectively. Combined imaging showed 100% sensitivity and 100% specificity. In group 2, FDG-PET and CEA were both positive in 42.9%, and only CEA was falsely negative in all other cases. FDG-PET and TPA were both positive in 47.6%, and in 52.4% only FDG-PET was positive. NSE and SCC had 100% specificity; their sensitivity was 38% and 25%, respectively. Conclusion: FDG-PET diagnosis was improved by CT. Because the serum tumour markers were falsely negative in more than 50% and there were no falsely negative results for FDG-PET, combined imaging may allow reduction of cut-off values for conventional serum tumour markers.