RT Journal Article
SR Electronic
T1 Multiplicity of <em>EGFR</em> and <em>KRAS</em> Mutations in Non-small Cell Lung Cancer (NSCLC) Patients Treated with Tyrosine Kinase Inhibitors
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1667
OP 1671
VO 30
IS 5
A1 BENESOVA, LUCIE
A1 MINARIK, MAREK
A1 JANCARIKOVA, DANA
A1 BELSANOVA, BARBORA
A1 PESEK, MILOS
YR 2010
UL http://ar.iiarjournals.org/content/30/5/1667.abstract
AB Background: Concurrent presence of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) patients is relatively rare and their appearance is believed to be mutually exclusive. Tumours harbouring KRAS mutation are perceived as not being capable of response to tyrosine kinase inhibitor (TKI) therapy. Patients and Methods: This paper presents 5 case reports of patients with tumours harbouring multiple EGFR and/or KRAS mutations. There were 3 patients with EGFR mutations (2 × exon 19 deletions, 1 × L858R) combined with KRAS mutations (2 × Gly12Asp, 1 × Gly12Val), 1 patient with two EGFR mutations (exon 19 deletion + L858R) and 1 patient with two KRAS mutations (Ala11Pro + Gly12Val). Results: All EGFR+/KRAS+ patients had initially showed positive response to TKI treatment. The EGFR+/EGFR+ patient has exhibited strong rash and good response with the best survival, while the KRAS+/KRAS+ patient did not respond to TKI therapy. Conclusion: EGFR+/KRAS+ combination does not necessarily pose a negative prediction. This is probably due to the multiclonal character of the tumour displaying partial response in the EGFR+ subpopulation.