RT Journal Article
SR Electronic
T1 Long-term Survival Is Linked to Serum LDH and Partly to Tumour LDH-5 in NSCLC
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1347
OP 1351
VO 30
IS 4
A1 DANNER, BERNHARD C.
A1 DIDILIS, VASSILIOS N.
A1 WIEMEYER, STEFAN
A1 STOJANOVIC, TOMISLAV
A1 KITZ, JULIA
A1 EMMERT, ALEXANDER
A1 FÜZESI, LASZLO
A1 SCHÖNDUBE, FRIEDRICH A.
YR 2010
UL http://ar.iiarjournals.org/content/30/4/1347.abstract
AB Background: Lactate formation is up-regulated in tumorous cells by lactate dehydrogenase (LDH). High serum LDH level is linked to many malignancies with poorer survival, but tumour LDH-5 has not been well investigated in non-small cell lung cancer (NSCLC). Patients and Methods: In 89 patients operated on for NSCLC stage I-III, the serum LDH level was assayed and immunohistochemistry for tumour LDH-5 was performed. Impact on long-term survival and correlation was analysed. Results: High serum LDH was associated with poorer survival (p<0.001). No correlation was revealed between serum LDH and the tumour LDH-5. Only in tumours greater than 3 cm were high tumour LDH-5 values associated with higher serum LDH values (p=0.04) and in this subgroup, high tumor LDH-5 was associated with poorer long-term survival (p=0.024). Conclusion: High serum LDH has a negative impact on long-term survival in NSCLC, whereas for tumour LDH-5, this was seen only in a subgroup of patients with larger tumours. Copyright© 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved