PT  - JOURNAL ARTICLE
AU  - DANNER, BERNHARD C.
AU  - DIDILIS, VASSILIOS N.
AU  - WIEMEYER, STEFAN
AU  - STOJANOVIC, TOMISLAV
AU  - KITZ, JULIA
AU  - EMMERT, ALEXANDER
AU  - FÜZESI, LASZLO
AU  - SCHÖNDUBE, FRIEDRICH A.
TI  - Long-term Survival Is Linked to Serum LDH and Partly to Tumour LDH-5 in NSCLC
DP  - 2010 Apr 01
TA  - Anticancer Research
PG  - 1347--1351
VI  - 30
IP  - 4
4099  - http://ar.iiarjournals.org/content/30/4/1347.short
4100  - http://ar.iiarjournals.org/content/30/4/1347.full
SO  - Anticancer Res2010 Apr 01; 30
AB  - Background: Lactate formation is up-regulated in tumorous cells by lactate dehydrogenase (LDH). High serum LDH level is linked to many malignancies with poorer survival, but tumour LDH-5 has not been well investigated in non-small cell lung cancer (NSCLC). Patients and Methods: In 89 patients operated on for NSCLC stage I-III, the serum LDH level was assayed and immunohistochemistry for tumour LDH-5 was performed. Impact on long-term survival and correlation was analysed. Results: High serum LDH was associated with poorer survival (p<0.001). No correlation was revealed between serum LDH and the tumour LDH-5. Only in tumours greater than 3 cm were high tumour LDH-5 values associated with higher serum LDH values (p=0.04) and in this subgroup, high tumor LDH-5 was associated with poorer long-term survival (p=0.024). Conclusion: High serum LDH has a negative impact on long-term survival in NSCLC, whereas for tumour LDH-5, this was seen only in a subgroup of patients with larger tumours. Copyright© 2010 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved