TY - JOUR T1 - Nuclear Expression of 14-3-3 Sigma Is Related to Prognosis in Patients with Esophageal Squamous Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 5175 LP - 5179 VL - 30 IS - 12 AU - HIROSHI OKUMURA AU - YOSHIAKI KITA AU - NAOYA YOKOMAKURA AU - YASUTO UCHIKADO AU - TETSURO SETOYAMA AU - HIDETOSHI SAKURAI AU - ITARU OMOTO AU - MASATAKA MATSUMOTO AU - TETSUHIRO OWAKI AU - SUMIYA ISHIGAMI AU - SHOJI NATSUGOE Y1 - 2010/12/01 UR - http://ar.iiarjournals.org/content/30/12/5175.abstract N2 - Background: The 14-3-3 sigma gene is transcriptionally activated by p53 after DNA damage and facilitates DNA repair during G2 arrest. The present study analyzed the clinical significance of 14-3-3 sigma expression in esophageal squamous cell carcinoma. Patients and Methods: The relationship between 14-3-3 sigma and p53 expressions was investigated immunohistochemically in surgical specimens of primary tumors from 248 patients with esophageal squamous cell carcinoma. Results: The positive expression rates of cytoplasmic and nuclear14-3-3 sigma were 61.7% and 41.9%, respectively. There was no correlation between 14-3-3 sigma and p53 expression. Positive expression of nuclear 14-3-3 sigma was significantly correlated with depth of invasion, stage, lymphatic invasion, and poor prognosis. Multivariate analysis indicated that negative expression of nuclear 14-3-3 sigma was an independent prognostic factor. Conclusion: Evaluation of the expression of nuclear 14-3-3 sigma proteins may be useful in predicting the outcome in patients with esophageal squamous cell carcinoma. ER -