RT Journal Article
SR Electronic
T1 Clinical Impacts of Histological Subtyping Primary Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5137
OP 5144
VO 30
IS 12
A1 P. FRITZ
A1 S. KLENK
A1 S. GOLETZ
A1 A. GERTEIS
A1 W. SIMON
A1 F. BRINKMANN
A1 E. HEIDEMANN
A1 E. LÜTTTGEN
A1 G. OTT
A1 M.D. ALSCHER
A1 M. SCHWAB
A1 J. DIPPON
YR 2010
UL http://ar.iiarjournals.org/content/30/12/5137.abstract
AB Background: Treatment decisions in breast cancer depend on TNM classification and the assessment of additional variables with have an impact on survival. We examined whether histological subtyping breast cancer as either ductal or lobular is related to disease outcome. Patients and Methods: We examined a large data base of 14198 breast cancer patients. Results: Histological sub-classification of invasive breast cancer as either ductal or lobular is not correlated with disease outcome. However, the data further showed that invasive lobular carcinomas have a higher probability of being oestrogen receptor (ER)- and progesterone receptor (PR)-positive and a lower probability of being c-erbB2-positive. They also showed a higher average age at the time of diagnosis in comparison with invasive ductal carcinoma. Local recurrence rates were lower in invasive lobular carcinoma in comparison with invasive ductal carcinoma (3.5% vs. 6.2%; p=0.031). The multivariable Cox regression analysis showed that ER, PR, nodal status, grade and tumour size predicted disease outcome with statistical significance, while the histological subtype (invasive ductal or lobular) was not a significant predictor of disease outcome. Conclusion: Histological sub-classification of invasive breast cancer as either ductal or lobular is not correlated with disease outcome. On the other hand our data gives some indication that lobular and ductal breast cancer appear to be different biological entities.