TY - JOUR T1 - Clinical Impacts of Histological Subtyping Primary Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 5137 LP - 5144 VL - 30 IS - 12 AU - P. FRITZ AU - S. KLENK AU - S. GOLETZ AU - A. GERTEIS AU - W. SIMON AU - F. BRINKMANN AU - E. HEIDEMANN AU - E. LÜTTTGEN AU - G. OTT AU - M.D. ALSCHER AU - M. SCHWAB AU - J. DIPPON Y1 - 2010/12/01 UR - http://ar.iiarjournals.org/content/30/12/5137.abstract N2 - Background: Treatment decisions in breast cancer depend on TNM classification and the assessment of additional variables with have an impact on survival. We examined whether histological subtyping breast cancer as either ductal or lobular is related to disease outcome. Patients and Methods: We examined a large data base of 14198 breast cancer patients. Results: Histological sub-classification of invasive breast cancer as either ductal or lobular is not correlated with disease outcome. However, the data further showed that invasive lobular carcinomas have a higher probability of being oestrogen receptor (ER)- and progesterone receptor (PR)-positive and a lower probability of being c-erbB2-positive. They also showed a higher average age at the time of diagnosis in comparison with invasive ductal carcinoma. Local recurrence rates were lower in invasive lobular carcinoma in comparison with invasive ductal carcinoma (3.5% vs. 6.2%; p=0.031). The multivariable Cox regression analysis showed that ER, PR, nodal status, grade and tumour size predicted disease outcome with statistical significance, while the histological subtype (invasive ductal or lobular) was not a significant predictor of disease outcome. Conclusion: Histological sub-classification of invasive breast cancer as either ductal or lobular is not correlated with disease outcome. On the other hand our data gives some indication that lobular and ductal breast cancer appear to be different biological entities. ER -