@article {ASSAO2755, author = {AGNES ASSAO and PAULA MIDORI YOSHINO and MARIA CAROLINA MALTA MEDEIROS and ANDR{\'E} LOPES CARVALHO and FERNANDO AUGUSTO SOARES and LUIZ PAULO KOWALSKI and DENISE TOSTES OLIVEIRA}, title = {Moesin Involvement in Oral Carcinogenesis of the Lower Lip}, volume = {38}, number = {5}, pages = {2755--2760}, year = {2018}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: This study analyzed moesin immunoexpression in 91 lip squamous cell carcinomas and its influence in patients{\textquoteright} prognosis. Materials and Methods: Moesin immunoexpression was evaluated at the invasive tumor front by a semi-quantitative score method. The association of moesin with the clinicopathological variables was analyzed by the Chi-square test, the survival rates were calculated by Kaplan{\textendash}Meier and the survival curves compared using the log-rank test. Results: The expression of moesin was strong at the invasive tumor front and weak/negative in differentiated cells such as keratin pearls. There was no association between moesin expression and the clinicopathological variables, but there was a tendency for patients with lip cancer and strong moesin expression to have lower 5- and 10-year overall and disease-free survival rates. Conclusion: Our results confirm the participation of moesin in oral carcinogenesis and suggest that this protein can influence the survival rates of patients with lip squamous cell carcinoma.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/38/5/2755}, eprint = {https://ar.iiarjournals.org/content/38/5/2755.full.pdf}, journal = {Anticancer Research} }