RT Journal Article SR Electronic T1 Down-regulation of Mus81 as a Potential Marker for the Malignancy of Gastric Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5011 OP 5014 VO 30 IS 12 A1 WU, FAN A1 SHIRAHATA, ATSUSHI A1 SAKURABA, KAZUMA A1 KITAMURA, YOHEI A1 GOTO, TETSUHIRO A1 SAITO, MITSUO A1 ISHIBASHI, KAZUYOSHI A1 KIGAWA, GAKU A1 NEMOTO, HIROSHI A1 SANADA, YUTAKA A1 HIBI, KENJI YR 2010 UL http://ar.iiarjournals.org/content/30/12/5011.abstract AB Background: The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. In the present study, the role of Mus81 in gastric cancer was explored. Materials and Methods: Mus81 expression in 53 cases of gastric cancer and the corresponding normal tissues was determined by quantitative real-time PCR. The correlations between Mus81 down-regulation and the clinicopathological data were also evaluated. Results: Mus81 expression was significantly lower in gastric cancer tissues than the corresponding normal tissues (p=0.018) and the down-regulation of Mus81 occurred in 51% (27/53) of the gastric carcinomas. More importantly, Mus81 down-regulation correlated significantly to invasion depth (p=0.015) and poorly-differentiated type (p=0.016) of gastric cancer. Conclusion: Mus81 might be a potential marker for the malignancy of gastric cancer.