PT  - JOURNAL ARTICLE
AU  - WU, FAN
AU  - SHIRAHATA, ATSUSHI
AU  - SAKURABA, KAZUMA
AU  - KITAMURA, YOHEI
AU  - GOTO, TETSUHIRO
AU  - SAITO, MITSUO
AU  - ISHIBASHI, KAZUYOSHI
AU  - KIGAWA, GAKU
AU  - NEMOTO, HIROSHI
AU  - SANADA, YUTAKA
AU  - HIBI, KENJI
TI  - Down-regulation of <em>Mus81</em> as a Potential Marker for the Malignancy of Gastric Cancer
DP  - 2010 Dec 01
TA  - Anticancer Research
PG  - 5011--5014
VI  - 30
IP  - 12
4099  - http://ar.iiarjournals.org/content/30/12/5011.short
4100  - http://ar.iiarjournals.org/content/30/12/5011.full
SO  - Anticancer Res2010 Dec 01; 30
AB  - Background: The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. In the present study, the role of Mus81 in gastric cancer was explored. Materials and Methods: Mus81 expression in 53 cases of gastric cancer and the corresponding normal tissues was determined by quantitative real-time PCR. The correlations between Mus81 down-regulation and the clinicopathological data were also evaluated. Results: Mus81 expression was significantly lower in gastric cancer tissues than the corresponding normal tissues (p=0.018) and the down-regulation of Mus81 occurred in 51% (27/53) of the gastric carcinomas. More importantly, Mus81 down-regulation correlated significantly to invasion depth (p=0.015) and poorly-differentiated type (p=0.016) of gastric cancer. Conclusion: Mus81 might be a potential marker for the malignancy of gastric cancer.