TY - JOUR T1 - HE4 Expression Can Be Associated with Lymph Node Metastases and Disease-free Survival in Breast Cancer JF - Anticancer Research JO - Anticancer Res SP - 4779 LP - 4783 VL - 30 IS - 11 AU - MIREI KAMEI AU - SHIN-ICHI YAMASHITA AU - KEITA TOKUISHI AU - TAKAFUMI HASHIOTO AU - TOSHIHIKO MOROGA AU - SHUJI SUEHIRO AU - KIYOSHI ONO AU - MICHIYO MIYAWAKI AU - SHINSUKE TAKENO AU - SATOSHI YAMAMOTO AU - KATSUNOBU KAWAHARA Y1 - 2010/11/01 UR - http://ar.iiarjournals.org/content/30/11/4779.abstract N2 - Background: This study investigated the potential of HE4 to predict disease-free survival for patients with breast cancer. Patients and Methods: One hundred and twenty-nine patients with breast cancer underwent surgery from January 2004 to September 2009. Immunohistochemical analysis (IHC) and RT-PCR were used to determine the expression of HE4 which was compared with the clinicopathological factors or prognosis. Results: A total of 71 of 129 cases (55%) were HE4 positive and two cell lines expressed HE4 protein and mRNA. No correlation was found between HE4 expression by IHC and clinicopathological factors; however, lymph node involvement was closely associated with HE4 expression. Five-year disease-free survival in the HE4-positive group (58.6%) was significantly worse than that in the negative group (85.6%, p=0.04). Conclusion: These data showed that HE4 expression is associated with lymph node involvement and is a possible predictive factor of breast cancer recurrence. ER -