RT Journal Article
SR Electronic
T1 Clinical Significance of Vimentin-positive Gastric Cancer Cells
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5239
OP 5243
VO 30
IS 12
A1 YUHIKO FUYUHIRO
A1 MASAKAZU YASHIRO
A1 SATORU NODA
A1 SHINICHIRO KASHIWAGI
A1 JUNKO MATSUOKA
A1 YOSUKE DOI
A1 YUKIHIRO KATO
A1 NAOSHI KUBO
A1 MASAICHI OHIRA
A1 KOSEI HIRAKAWA
YR 2010
UL http://ar.iiarjournals.org/content/30/12/5239.abstract
AB Background/Aim: Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric cancer (GC). Patients and Methods: A total of 265 GCs were examined by immunofluorescent staining with antibodies against vimentin and carcinoembryonic antigen. GCs were determined to be vimentin-positive when cells were positive for both vimentin and carcinoembryonic antigen staining. Results: A total of 86 (32%) of 265 GCs were vimentin positive. There was a statistically significant correlation between vimentin-positive GCs and advanced clinical stage (p<0.001), macroscopic scirrhous-type (p<0.001), histological diffuse-type (p<0.001), lymph node metastasis (p=0.008) and lymphatic invasion (p=0.013). The prognosis of patients with vimentin-positive GCs was significantly (p<0.001) worse than that with vimentin-negative GCs. Conclusion: Vimentin expression might contribute to the high invasive phenotype of GC, and may be a useful biomarker to determine the biological aggressiveness of GC.