PT  - JOURNAL ARTICLE
AU  - KOJI OBA
AU  - MICHIYA KOBAYASHI
AU  - TAKANORI MATSUI
AU  - YASUHIRO KODERA
AU  - JUNICHI SAKAMOTO
TI  - Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer
DP  - 2009 Jul 01
TA  - Anticancer Research
PG  - 2739--2745
VI  - 29
IP  - 7
4099  - http://ar.iiarjournals.org/content/29/7/2739.short
4100  - http://ar.iiarjournals.org/content/29/7/2739.full
SO  - Anticancer Res2009 Jul 01; 29
AB  - Background: In the present study, the effect of immunochemotherapy with lentinan compared with that of chemotherapy alone was evaluated in patients with advanced gastric cancer through individual patient data (IPD) meta-analysis. Materials and Methods: Based on a computerized and manual search, all eligible centrally randomized controlled trials (RCT) which compared chemotherapy regimens with or without lentinan administration for advanced gastric cancer patients were included. Results: In total, 650 IPD from 5 trials were available. Lentinan significantly prolonged the overall survival (stratified log-rank p=0.011). The overall hazard ratio (HR) was 0.80 (95% confidence interval=0.68-0.95) and there was no heterogeneity between trials. Additionally, lentinan was possibly more effective in patients with lymph-node metastasis than in non-node metastasis patients (P for interaction=0.077). Conclusion: The addition of lentinan to standard chemotherapy offers a significant advantage over chemotherapy alone in terms of survival for patients with advanced gastric cancer.