There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. Other recent studies have now also demonstrated how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer. Furthermore it presents new information which applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.
Key features of the book: 1. Offers a synthesis of concepts that are useful to cancer immunologists and pharmacologists, who tend to work in disparate fields with little cross-communication; 2. Summarizes the latest insights into how immune escape defines an essential trait of cancer; 3. Describes how molecular-targeted therapeutic drugs or traditional chemotherapy can be combined with immunotherapy to improve anti-tumor efficacy; and how reversing immune suppression by the tumor can cause tumor regression.
- Copyright© 2013 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved