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Research ArticleClinical Studies

Macroscopic Tumor Color as a Surrogate for Biological Diversity in Clear Cell Renal Cell Carcinoma

NOZOMI TSUJIO, CHISATO OHE, MASANORI SHIOHARA, NAO YUKIMATSU, TAKESHI YAMASAKI, MASAHIRO KATO, RENA UNO, JUNJI UCHIDA and KENICHI KOHASHI
Anticancer Research May 2026, 46 (5) 2683-2692; DOI: https://doi.org/10.21873/anticanres.18148
NOZOMI TSUJIO
1Department of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
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CHISATO OHE
1Department of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
2Department of Surgical Pathology, Hyogo Medical University, Hyogo, Japan;
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  • For correspondence: ohec{at}hyo-med.ac.jp
MASANORI SHIOHARA
1Department of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
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NAO YUKIMATSU
3Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
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TAKESHI YAMASAKI
3Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
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MASAHIRO KATO
1Department of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
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RENA UNO
4Department of Pathology, Hyogo Cancer Center, Hyogo, Japan
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JUNJI UCHIDA
3Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
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KENICHI KOHASHI
1Department of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
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Article Information

vol. 46 no. 5 2683-2692
DOI 
https://doi.org/10.21873/anticanres.18148
PMID 
42049324

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received February 27, 2026
  • Revision received March 19, 2026
  • Accepted March 24, 2026
  • Published online April 28, 2026.

Copyright & Usage 
Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. NOZOMI TSUJIO1,
  2. CHISATO OHE1,2⇑,
  3. MASANORI SHIOHARA1,
  4. NAO YUKIMATSU3,
  5. TAKESHI YAMASAKI3,
  6. MASAHIRO KATO1,
  7. RENA UNO4,
  8. JUNJI UCHIDA3 and
  9. KENICHI KOHASHI1
  1. 1Department of Pathology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
  2. 2Department of Surgical Pathology, Hyogo Medical University, Hyogo, Japan;
  3. 3Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan;
  4. 4Department of Pathology, Hyogo Cancer Center, Hyogo, Japan
  1. Chisato Ohe, Department of Surgical Pathology, Hyogo Medical University, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. Tel: +81 798456324, Fax: +81 798456325, e-mail: ohec{at}hyo-med.ac.jp
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Anticancer Research: 46 (5)
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Macroscopic Tumor Color as a Surrogate for Biological Diversity in Clear Cell Renal Cell Carcinoma
NOZOMI TSUJIO, CHISATO OHE, MASANORI SHIOHARA, NAO YUKIMATSU, TAKESHI YAMASAKI, MASAHIRO KATO, RENA UNO, JUNJI UCHIDA, KENICHI KOHASHI
Anticancer Research May 2026, 46 (5) 2683-2692; DOI: 10.21873/anticanres.18148

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Macroscopic Tumor Color as a Surrogate for Biological Diversity in Clear Cell Renal Cell Carcinoma
NOZOMI TSUJIO, CHISATO OHE, MASANORI SHIOHARA, NAO YUKIMATSU, TAKESHI YAMASAKI, MASAHIRO KATO, RENA UNO, JUNJI UCHIDA, KENICHI KOHASHI
Anticancer Research May 2026, 46 (5) 2683-2692; DOI: 10.21873/anticanres.18148
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Keywords

  • Clear cell renal cell carcinoma
  • macroscopic color
  • intratumoral heterogeneity
  • tissue sampling
  • risk stratification
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