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Research ArticleExperimental Studies

Ubiquitin Ligase RNF149 Promotes Head and Neck Cancer Growth via Downregulation of CDKN2C

YU-HSUAN HUNG, MIN-HONG WANG, LI-TZONG CHEN, MEI-REN PAN, HUI-CHING WANG, SIN-HUA MOI and CHI-WEN LUO
Anticancer Research May 2026, 46 (5) 2551-2564; DOI: https://doi.org/10.21873/anticanres.18137
YU-HSUAN HUNG
1Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
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  • For correspondence: yhhung2021{at}gmail.com 1120413{at}kmuh.org.tw
MIN-HONG WANG
2Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
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LI-TZONG CHEN
3Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
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MEI-REN PAN
4Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
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HUI-CHING WANG
2Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
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SIN-HUA MOI
4Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
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CHI-WEN LUO
5Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
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Article Information

vol. 46 no. 5 2551-2564
DOI 
https://doi.org/10.21873/anticanres.18137
PMID 
42049330

Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received February 7, 2026
  • Revision received March 11, 2026
  • Accepted March 30, 2026
  • Published online April 28, 2026.

Copyright & Usage 
Copyright © 2026 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Author Information

  1. YU-HSUAN HUNG1⇑*,
  2. MIN-HONG WANG2,*,
  3. LI-TZONG CHEN3,
  4. MEI-REN PAN4,
  5. HUI-CHING WANG2,
  6. SIN-HUA MOI4 and
  7. CHI-WEN LUO5
  1. 1Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
  2. 2Division of Hematology and Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
  3. 3Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
  4. 4Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.;
  5. 5Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
  1. Yu-Hsuan Hung, Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C. Tel: +886 926045957, e-mail: yhhung2021{at}gmail.com and 1120413{at}kmuh.org.tw
  1. ↵* These Authors contributed equally to this work.

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Ubiquitin Ligase RNF149 Promotes Head and Neck Cancer Growth via Downregulation of CDKN2C
YU-HSUAN HUNG, MIN-HONG WANG, LI-TZONG CHEN, MEI-REN PAN, HUI-CHING WANG, SIN-HUA MOI, CHI-WEN LUO
Anticancer Research May 2026, 46 (5) 2551-2564; DOI: 10.21873/anticanres.18137

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Ubiquitin Ligase RNF149 Promotes Head and Neck Cancer Growth via Downregulation of CDKN2C
YU-HSUAN HUNG, MIN-HONG WANG, LI-TZONG CHEN, MEI-REN PAN, HUI-CHING WANG, SIN-HUA MOI, CHI-WEN LUO
Anticancer Research May 2026, 46 (5) 2551-2564; DOI: 10.21873/anticanres.18137
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Keywords

  • RNF149
  • head and neck squamous cell carcinoma
  • HNSC
  • CDKN2C
  • CGP60474
  • proximity ligation assay
  • PLA
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