Therapeutic Efficacy of PB101 and Chemotherapy Combination in Preclinical Gastric Cancer Models

MINSUNG PARK; CHENG HYUN LEE; KUI-JIN KIM; SUNG-HYUN HWANG; JI HEA SUNG; MILANG NAM; MINSU KANG; WOOCHAN PARK; JI-WON KIM; JIN WON KIM; SE HYUN KIM; JEONGMIN SEO; EUN HEE JUNG; KOUNG JIN SUH; YU JUNG KIM; JEE HYUN KIM; HYE SEONG LIM; HYUN GUL YANG; EUN BYUL CHO; KEUN-WOOK LEE

doi:10.21873/anticanres.18128

Research ArticleExperimental Studies

Therapeutic Efficacy of PB101 and Chemotherapy Combination in Preclinical Gastric Cancer Models

MINSUNG PARK, CHENG HYUN LEE, KUI-JIN KIM, SUNG-HYUN HWANG, JI HEA SUNG, MILANG NAM, MINSU KANG, WOOCHAN PARK, JI-WON KIM, JIN WON KIM, SE HYUN KIM, JEONGMIN SEO, EUN HEE JUNG, KOUNG JIN SUH, YU JUNG KIM, JEE HYUN KIM, HYE SEONG LIM, HYUN GUL YANG, EUN BYUL CHO and KEUN-WOOK LEE

Anticancer Research May 2026, 46 (5) 2429-2443; DOI: https://doi.org/10.21873/anticanres.18128

MINSUNG PARK

1Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;

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CHENG HYUN LEE

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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KUI-JIN KIM

3Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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SUNG-HYUN HWANG

3Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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JI HEA SUNG

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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MILANG NAM

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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MINSU KANG

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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WOOCHAN PARK

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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JI-WON KIM

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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JIN WON KIM

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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SE HYUN KIM

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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JEONGMIN SEO

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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EUN HEE JUNG

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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KOUNG JIN SUH

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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YU JUNG KIM

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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JEE HYUN KIM

1Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

3Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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HYE SEONG LIM

4Panolos Bioscience, Inc., Hwaseong, Republic of Korea

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HYUN GUL YANG

4Panolos Bioscience, Inc., Hwaseong, Republic of Korea

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EUN BYUL CHO

4Panolos Bioscience, Inc., Hwaseong, Republic of Korea

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KEUN-WOOK LEE

1Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;

2Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

3Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;

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For correspondence: imdoctor{at}snu.ac.kr

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vol. 46 no. 5 2429-2443

DOI

https://doi.org/10.21873/anticanres.18128

PMID

42049328

Published By

International Institute of Anticancer Research

Print ISSN

0250-7005

Online ISSN

1791-7530

History

Received January 13, 2026
Revision received February 11, 2026
Accepted March 6, 2026
Published online April 28, 2026.

Author Information

MINSUNG PARK¹,*,
CHENG HYUN LEE²,*,
KUI-JIN KIM³,
SUNG-HYUN HWANG³,
JI HEA SUNG²,
MILANG NAM²,
MINSU KANG²,
WOOCHAN PARK²,
JI-WON KIM²,
JIN WON KIM²,
SE HYUN KIM²,
JEONGMIN SEO²,
EUN HEE JUNG²,
KOUNG JIN SUH²,
YU JUNG KIM²,
JEE HYUN KIM¹,²,³,
HYE SEONG LIM⁴,
HYUN GUL YANG⁴,
EUN BYUL CHO⁴ and
KEUN-WOOK LEE¹,²,³ ⇑

¹Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea;
²Division of Hematology and Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;
³Biomedical Research Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;
⁴Panolos Bioscience, Inc., Hwaseong, Republic of Korea

Keun-Wook Lee, MD, PhD, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82 Gumi-ro 173 Beon-gil Bundang-gu, Seongnam 13620, Republic of Korea. Tel: +82 317877039, e-mail: imdoctor{at}snu.ac.kr

↵* These Authors contributed equally to this work.

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Therapeutic Efficacy of PB101 and Chemotherapy Combination in Preclinical Gastric Cancer Models

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Keywords

gastric cancer
VEGF
PlGF
anti-angiogenic therapy
PB101
combination therapy

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