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Serum Extracellular Vesicles Double-positive for CD9 and CD147 or for CD9 and CD63 Decrease After Surgical Resection in Patients With Colorectal Cancer: Potential Biomarkers of Residual Tumor

YUKARI ADACHI, TAKERU MATSUDA, SACHIKO INUBUSHI, KEISUKE YASUDA, RYOTA ITO, NAOTO SHIRAKAMI, TAKAAKI TACHIBANA, MASAKI IMAI, HIROKI KAGIYAMA, TAKAO TSUNEKI, MASAYUKI ANDO, MASAFUMI SAITO, YUTAKA SUGITA, TARO IKEDA, YASUFUMI KOTERAZAWA, TOMOAKI AOKI, HITOSHI HARADA, YASUNORI OTOWA, NAOKI URAKAWA, HIRONOBU GOTO, HIROSHI HASEGAWA, SHINGO KANAJI, KIMIHIRO YAMASHITA, ROBERT M. HOFFMAN and YOSHIHIRO KAKEJI
Anticancer Research May 2026, 46 (5) 2345-2352; DOI: https://doi.org/10.21873/anticanres.18121

Article Information

vol. 46 no. 5 2345-2352
DOI 
https://doi.org/10.21873/anticanres.18121
PMID 
42049365
Published By 
International Institute of Anticancer Research
Print ISSN 
0250-7005
Online ISSN 
1791-7530
History 
  • Received February 3, 2026
  • Revision received March 10, 2026
  • Accepted March 12, 2026
  • Published online April 28, 2026.
Copyright & License 
Copyright © 2026 The Author(s). Published by the International Institute of Anticancer Research. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Author Information

  1. YUKARI ADACHI1,
  2. TAKERU MATSUDA1,
  3. SACHIKO INUBUSHI2⇑,
  4. KEISUKE YASUDA1,
  5. RYOTA ITO1,
  6. NAOTO SHIRAKAMI1,
  7. TAKAAKI TACHIBANA1,
  8. MASAKI IMAI1,
  9. HIROKI KAGIYAMA1,
  10. TAKAO TSUNEKI1,
  11. MASAYUKI ANDO1,
  12. MASAFUMI SAITO3,
  13. YUTAKA SUGITA1,
  14. TARO IKEDA1,
  15. YASUFUMI KOTERAZAWA1,
  16. TOMOAKI AOKI1,
  17. HITOSHI HARADA1,
  18. YASUNORI OTOWA1,
  19. NAOKI URAKAWA1,
  20. HIRONOBU GOTO1,
  21. HIROSHI HASEGAWA1,
  22. SHINGO KANAJI1,
  23. KIMIHIRO YAMASHITA4,
  24. ROBERT M. HOFFMAN5,6 and
  25. YOSHIHIRO KAKEJI1⇑
  1. 1Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan;
  2. 2Division of Breast Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, Kobe, Japan;
  3. 3Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Japan;
  4. 4Division of Analytical Biomedical Sciences, Department of Biophysics, Graduate School of Health Sciences, Kobe University, Kobe, Japan;
  5. 5AntiCancer Inc, San Diego, CA, U.S.A.;
  6. 6Department of Surgery, University of California San Diego, La Jolla, CA, U.S.A.
  1. Sachiko Inubushi, PhD, Division of Breast Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan. Tel: +81 783825111, e-mail: sachiko_inubushi{at}people.kobe-u.ac.jp
  2. Yoshihiro Kakeji, MD, PhD, Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan. Tel: +81 783825925, e-mail: kakeji{at}med.kobe-u.ac.jp
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Serum Extracellular Vesicles Double-positive for CD9 and CD147 or for CD9 and CD63 Decrease After Surgical Resection in Patients With Colorectal Cancer: Potential Biomarkers of Residual Tumor
YUKARI ADACHI, TAKERU MATSUDA, SACHIKO INUBUSHI, KEISUKE YASUDA, RYOTA ITO, NAOTO SHIRAKAMI, TAKAAKI TACHIBANA, MASAKI IMAI, HIROKI KAGIYAMA, TAKAO TSUNEKI, MASAYUKI ANDO, MASAFUMI SAITO, YUTAKA SUGITA, TARO IKEDA, YASUFUMI KOTERAZAWA, TOMOAKI AOKI, HITOSHI HARADA, YASUNORI OTOWA, NAOKI URAKAWA, HIRONOBU GOTO, HIROSHI HASEGAWA, SHINGO KANAJI, KIMIHIRO YAMASHITA, ROBERT M. HOFFMAN, YOSHIHIRO KAKEJI
Anticancer Research May 2026, 46 (5) 2345-2352; DOI: 10.21873/anticanres.18121
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